The new issue of *Archives of General Psychiatry* (Vol. 66 No. 10)
includes an article: “Association of the Mediterranean Dietary Pattern
With the Incidence of Depression.”
The authors are Almudena Sánchez-Villegas, BPharm, PhD; Miguel Delgado-
Rodríguez, MD, PhD, MPH; Alvaro Alonso, MD, PhD; Javier Schlatter, MD,
PhD; Francisca Lahortiga, BA, PhD; Lluis Serra Majem, MD, PhD; & Miguel
Angel Martínez-González, MD, PhD, MPH.
Here’s the abstract:
Context
Adherence to the Mediterranean dietary pattern (MDP) is thought to
reduce inflammatory, vascular, and metabolic processes that may be
involved in the risk of clinical depression.
Objective
To assess the association between adherence to the MDP and the incidence
of clinical depression.
Design
Prospective study that uses a validated 136-item food frequency
questionnaire to assess adherence to the MDP. The MDP score positively
weighted the consumption of vegetables, fruit and nuts, cereal, legumes,
and fish; the monounsaturated- to saturated-fatty-acids ratio; and
moderate alcohol consumption, whereas meat or meat products and whole-
fat dairy were negatively weighted.
Setting
A dynamic cohort of university graduates (Seguimiento Universidad de
Navarra/University of Navarra Follow-up [SUN] Project).
Participants
A total of 10,094 initially healthy Spanish participants from the SUN
Project participated in the study. Recruitment began on December 21,
1999, and is ongoing.
Main Outcome Measure
Participants were classified as having incident depression if they were
free of depression and antidepressant medication at baseline and
reported a physician-made diagnosis of clinical depression and/or
antidepressant medication use during follow-up.
Results
After a median follow-up of 4.4 years, 480 new cases of depression were
identified. The multiple adjusted hazard ratios (95% confidence
intervals) of depression for the 4 upper successive categories of
adherence to the MDP (taking the category of lowest adherence as
reference) were 0.74 (0.57-0.98), 0.66 (0.50-0.86), 0.49 (0.36-0.67),
and 0.58 (0.44-0.77) (P for trend <.001). Inverse dose-response
relationships were found for fruit and nuts, the monounsaturated- to
saturated-fatty-acids ratio, and legumes.
Conclusions
Our results suggest a potential protective role of the MDP with regard
to the prevention of depressive disorders; additional longitudinal
studies and trials are needed to confirm these findings.

The new issue of *Archives of General Psychiatry* (Vol. 66 No. 10)includes an article: “Association of the Mediterranean Dietary PatternWith the Incidence of Depression.”
The authors are Almudena Sánchez-Villegas, BPharm, PhD; Miguel Delgado-Rodríguez, MD, PhD, MPH; Alvaro Alonso, MD, PhD; Javier Schlatter, MD,PhD; Francisca Lahortiga, BA, PhD; Lluis Serra Majem, MD, PhD; & MiguelAngel Martínez-González, MD, PhD, MPH.
Here’s the abstract:
Context
Adherence to the Mediterranean dietary pattern (MDP) is thought toreduce inflammatory, vascular, and metabolic processes that may beinvolved in the risk of clinical depression.
Objective
To assess the association between adherence to the MDP and the incidenceof clinical depression.
Design
Prospective study that uses a validated 136-item food frequencyquestionnaire to assess adherence to the MDP. The MDP score positivelyweighted the consumption of vegetables, fruit and nuts, cereal, legumes,and fish; the monounsaturated- to saturated-fatty-acids ratio; andmoderate alcohol consumption, whereas meat or meat products and whole-fat dairy were negatively weighted.
Setting
A dynamic cohort of university graduates (Seguimiento Universidad deNavarra/University of Navarra Follow-up [SUN] Project).
Participants
A total of 10,094 initially healthy Spanish participants from the SUNProject participated in the study. Recruitment began on December 21,1999, and is ongoing.
Main Outcome Measure
Participants were classified as having incident depression if they werefree of depression and antidepressant medication at baseline andreported a physician-made diagnosis of clinical depression and/orantidepressant medication use during follow-up.
Results
After a median follow-up of 4.4 years, 480 new cases of depression wereidentified. The multiple adjusted hazard ratios (95% confidenceintervals) of depression for the 4 upper successive categories ofadherence to the MDP (taking the category of lowest adherence asreference) were 0.74 (0.57-0.98), 0.66 (0.50-0.86), 0.49 (0.36-0.67),and 0.58 (0.44-0.77) (P for trend <.001). Inverse dose-responserelationships were found for fruit and nuts, the monounsaturated- tosaturated-fatty-acids ratio, and legumes.
Conclusions
Our results suggest a potential protective role of the MDP with regardto the prevention of depressive disorders; additional longitudinalstudies and trials are needed to confirm these findings.

 

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